Advair Diskus Ingredients and Composition
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Advair Diskus Ingredients and Composition
Advair Diskus 100/50, Advair Diskus 250/50, and Advair Diskus 500/50 are combinations of fluticasone propionate and salmeterol xinafoate.
One active component of Advair Diskus is fluticasone propionate, a corticosteroid having the chemical name S-(fluoromethyl) 6a,9-difluoro-11b,17-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carbothioate, 17-propionate.
Fluticasone propionate is a white to off-white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.
The other active component of Advair Diskus is salmeterol xinafoate, a highly selective beta2-adrenergic bronchodilator. Salmeterol xinafoate is the racemic form of the 1-hydroxy-2-naphthoic acid salt of salmeterol. The chemical name of salmeterol xinafoate is 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedi-methanol, 1-hydroxy-2-naphthalenecarboxylate.
Salmeterol xinafoate is a white to off-white powder with a molecular weight of 603.8, and the empirical formula is C25H37NO4•C11H8O3. It is freely soluble in methanol; slightly soluble in ethanol, chloroform, and isopropanol; and sparingly soluble in water.
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