Despite the claims of some in the supplement industry, there exists ample scientific literature to substantiate the efficacy of Nitric Oxide products. The following was written in May 1996 in a document prepared for the Royal Society and Association of British Science Writers:
"Summary research papers continue to flood the scientific journals and insights into the biological activity and potential clinical uses of nitric oxide (NO): a gas controlling a seemingly limitless range of functions in the body. Each revelation adds to nitric oxide's already lengthy resume in controlling the circulation of the blood, regulating activities of the brain, lungs, liver, kidneys, stomach and other organs.
The molecule governs blood pressure through a recently recognized process that contradicts textbook wisdom. It causes penile erection by dilating blood vessels and controls the action of almost every orifice from swallowing to defecation. The immune system uses nitric oxide in fighting viral, bacterial and parasitic infections, and tumors. Nitric oxide transmits messages between nerve cells and is associated with the process of learning, memory, sleeping, feeling pain, and, probably depression. It is a mediator in inflammation and rheumatism."
Since the above was written in 1996, Nitric Oxide containing products have continued to be touted by those in the medical profession, as well as by athletes looking to add muscle to their frames.
The above quotation states that Nitric Oxide controls the circulation of blood, transmits messages between nerve cells, and is a mediator of inflammation and is associated with the process of feeling pain. The popular erectile dysfunction drug sildenafil citrate (Viagra) contains nitric oxide and is responsible for increasing blood flow to the penis - just as that in BSN Nitrix is to all muscle.
The fact that nitric oxide increases blood flow should make it of interest to bodybuilders, as increased blood flow will serve to deliver more nutrients to muscles, thus helping muscles become larger when subject to stress. The fact that Nitric Oxide acts to reduce inflammation should also make it of interest to bodybuilders as it has the potential to reduce the pain associated with subjecting muscles to extreme stress.
Nitric oxide also affects the endocrine system. It affects the release of gonadotroptin releasing hormone, as well as the release of adrenaline from the adrenal medulla.