Denavir Ingredients and Composition
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Denavir Ingredients and Composition
Denavir contains penciclovir, an antiviral agent active against herpes viruses. Denavir is available for topical administration as a 1% white cream. Each gram of Denavir contains 10 mg of penciclovir and the following inactive ingredients: cetomacrogol 1000 BP, cetostearyl alcohol, mineral oil, propylene glycol, purified water and white petrolatum.
Chemically penciclovir is known as 9-[4-hydroxy-3-(hydroxymethyl)butyl] guanine. Its molecular formula is C10H15N5O3; its molecular weight is 253. 26. It is a synthetic acyclic guanine derivative.
Penciclovir, the active ingredient in Denavir, is a white to pale yellow solid. At 20° C it has a solubility of 0.2 mg/mL in methanol, 1.3 mg/mL in propylene glycol, and 1.7 mg/mL in water. In aqueous buffer (pH 2) the solubility is 100 mg/mL. Penciclovir is not hygroscopic. Its partition coefficient in n-octanol/water at pH 7. 5 is 0.024 (logP=-1.62).
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