Flexeril Warnings

Flexeril Information

Flexeril Warnings

Cyclobenzaprine in Flexeril is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine. In short term studies for indications other than muscle spasm associated with acute musculoskeletal conditions, and usually at doses somewhat greater than those recommended for skeletal muscle spasm, some of the more serious central nervous system reactions noted with the tricyclic antidepressants have occurred.

Cyclobenzaprine HCl in Flexeril may interact with monoamine oxidase (MAO) inhibitors. Hyperpyretic crisis, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressants and MAO inhibitor drugs.

Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction, and stroke.

Flexeril may enhance the effects of alcohol, barbiturates, and other CNS depressants.

Flexeril Information