Hot-Rox

Hot-Rox Information

Other Common Names: Biotest Hot-Rox, Hot-Rox Thermogenix, HotRox

Biotest Hot Rox thermogenic pill is a a latest generation ephedra-free fat burner. Biotest is a well known and respected supplement maker that charters for the top end of the price range products. Hot Rox is a thermogenic weight loss drug, that the manufactuer claims: "makes ephedra obsolete". It does this by using a proprietary thermogenic formula which consists mainly of substances increasing lipase activity.

Biotest, the manufacturer of Hot Rox, claims that the product:

• is the newest and most unique fat loss phenomenon
• is more effective at burning off body fat than anything that has yet reached the market
• unlike ephedra-based formulas, does not down-regulate beta-receptor sites and become ineffective over time
• also increases protein synthesis and the natural production of anabolic substrates (benefiting muscle maintainance and/or building)
• metabolic benefits are sustained, around the clock, week after week, as long as you continue to taking it

Hot-Rox Nutritional Facts

Hot Rox Serving Size (caps) 2

Servings Per Bottle: 40

Hot-Rox Ingredients and Composition

How Does Hot-Rox Work?

This is how various Hot-Rox ingredients work, either respecitvely or synergically:

MDX complex

There are two main active ingredients: A7-E and sclaremax, with guggulsterone functioning as a 'booster'.

Guggulsterones increase the peripheral conversion of T4 into T3, making it the ideal complement to 7-keto DHEA. Increasing the peripheral conversion of T3 is highly important because the thyroid only produces 20% of the body's T3. Most of the remaining 80% is derived from T4 through a conversion process that occurs in various target tissues, like skeletal muscle, for example.

7-keto DHEA would have been a logical synergist for Guggulsterones in the Hot-Rox formula, but its bioavailability isn't high enough and its active life is far too short. Furthermore, of the entire family of androst-5-ene compounds researched, 7-keto DHEA didn't show the best performance when converting into the active species androst-5-ene-3,7,17-triol (A5-T). And since A5-T is the compound that elicits profound thermogenic actions, why not use the androst-5-ene derivative that shows the greatest conversion rate?

The best choice for Hot-Rox proved to be androst-5-ene-7-one-3,17-diol (A7-D), which has 3x better conversion into the active A5-T. So A7-D is our top choice for the job. And to improve both bioavailability and length of active life, Bill engineered A7-D into a carbonate ester, called androst-5-ene-7-one-3,17-diethylcarbonate, or A7-E.

A7-E, due to its superior rate of conversion into A5-T, its longer active life, and its increased bioavailability, represents a quantum leap beyond 7-keto DHEA, making it a real powerhouse for fat loss.

The second new active compound in HOT-ROX is called Sclaremax. Sclaremax is a diterpenoidal lactone found in a plant called Salvia sclarea. It's known to be an extremely potent adenylate cyclase activator, very similar to that of the diterpene derivative, forskolin. In fact, cyclic AMP assays indicate Sclaremax either equals or exceeds the actions of forskolin, but with a much longer active life.

Additionally, like forskolin, Sclaremax stimulates adenylate cyclase independently of beta-2 receptors, which means it has no limitations because it won't down-regulate and it has a higher maximal effect. In other words, the more you take, the greater the effect - day after day after day...

TSH activates adenylate cyclase in the membrane of thyroid cells, which in turn elevates cyclic AMP and eventually leads to thyroid hormones being released. So, Sclaremax essentially mimics or acts like TSH, which will further increase endogenous thyroid-hormone production. It may also enhance the cyclic AMP response to TSH in thyroid cells as well.

And because Sclaremax produces an accumulation of cyclic AMP, it will also increase nitrogen retention. This means that it will help preserve or even build lean-body mass (muscle) while increasing lipolysis.

Another huge bonus in comparison to ephedra and other beta agonists, Sclaremax doesn't interact with beta-1 adrenoreceptors and over stimulate cardiac tissue or raise blood pressure. In fact, Sclaremax, in very high doses, exhibits a vasodilatory effect and slightly decreases blood pressure.

Some other benefits of Sclaremax include its antithrombotic and antidepressant effects, as well as its stimulating effect on luteinizing hormone, via cyclic AMP, resulting in the production of Testosterone (in males).

Caffeine

Caffeine by itself is a thermogenic compound, and this is why they are used by Hot-Rox, as a synergist to Sclaremex. This plant chemical is rapidly absorbed by the body and remains in circulation for more than seven hours. Plasma concentrations reach a peak one hour after it is consumed. It is then slowly metabolized, with a half-life of four to six hours.

Caffeine has been shown to dramatically increase free fatty-acid levels, providing the body with a fuel source that it can use instead of the glycogen stored in your liver and muscles. In fact, one study found a 100% increase in plasma free fatty acids after the subjects took 330 mg of caffeine.

At the same time, caffeine has been shown to increase adrenaline levels. This "fight-or-flight" hormone increases alertness and boosts energy levels, helping you to go through your daily tasks with less food intake. Most people experience a reduced appetite when their adrenaline levels are high, usually because they are focused on more essential tasks. With these two mechanisms, it's easy to understand why caffeine in Hot-Rox is important for jump-starting your weight-loss efforts. Caffeine is also a potent competitive inhibitor of phosphodiesterase enzyme, which is responsible for the inactivation of cyclic AMP.

In comparison, Sclaremax increases the formation of cyclic AMP, whereas caffeine acts to prevent its degradation. In other words, caffeine potentiates the effects of Sclaremax, thus increasing the magnitude of cyclic AMP accumulation.

And since Sclaremax and caffeine increase cyclic AMP, but via different mechanisms and not through the beta receptor, a combination produces a powerful, synergistic effect on lipolysis.

So you can see that, even though A7-E, Sclaremax, guggulsterones, and caffeine have discrete roles in the fat-loss process, they also potentiate one another's activities, making the combination extremely powerful.

N-Acetyl-L-tyrosine

L-tyrosine is the amino acid tyrosine in free (unbound) form. Tyrosine is an amino acid that plays an important role in human metabolism. It is the precursor to stimulatory neurotransmitters such as epinephrine, norepinephrine, dopamine and some of the thyroid hormones. All of these neurotransmitters and hormones play important roles in maintaining your metabolic rate. Logically, if you have a greater supply of these precursors, you can nudge your metabolism up a bit, helping you to shed unwanted pounds. Several studies have also shown that tyrosine increases the benefits of caffeine/ephedrine products, in part by curbing appetite. Tyrosine appears to reduce stress and fatigue as well, putting you in a better state of mind and making it easier to stick to your diet and exercise program. The amount of L-tyrosine in Hot-Rox is not indicated on the product label.

Finally, Biotest - the manufacturer of Hot-Rox, claims that Hot-Rox:

• Ramps up lipolysis, releasing fat from adipocytes more rapidly than ephedra-based products to the point of no contest.
• Minimizes lipogenesis (fat creation) via increased cAMP and T3.
• Maximizes and sustains metabolism around the clock, turning fat into heat energy, through two powerful mechanisms: Fueling the TCA cycle, Stimulating mitochondrial uncoupling
• Provides an inexhaustible supply of the weak-link substrate oxaloacetate and thus keeps the TCA cycle primed for sustained, maximum fat burn.
• Elevates and maintains not only the increased production of T3, but the peripheral conversion of T4 into T3 as well, without suppressing TSH (natural thyroid production).
• Doesn't over stimulate cardiac tissue or raise blood pressure.
• Preserves or even promotes muscle-mass gains.

How To Take Hot-Rox and Hot-Rox Dosage and Administration

Use Hot-Rox a dietary supplement, take one or two capsules in the morning prior to breakfast and one or two capsules six hours later, each time on an empty stomach with 8 oz. of water. If you haven't used this supplement previously, begin by taking one capsule twice per day for three days prior to increasing the dose. Do not exceed four capsules in any 24-hour period.

For best results, Hot-Rox should be used for continuously for at least a month.

If you have trouble sleeping, do not take within 6 hours of bedtime.

If you suspect a Hot-Rox Overdose

There are no reports of Hot-Rox overdose.

Hot-Rox Side Effects

Hot-Rox Warnings

Contraindications to Hot-Rox

Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluted by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.