Lotronex Ingredients and Composition
Lotronex Information
Lotronex Ingredients and Composition
The active ingredient in Lotronex Tablets is alosetron hydrochloride (HCl), a potent and selective antagonist of the serotonin 5-HT3 receptor type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O•HCl, representing a molecular weight of 330.8. Alosetron is a white to beige solid that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1M hydrochloric acid, 0.3 mg/mL in pH 6 phosphate buffer, and <0.1 mg/mL in pH 8 phosphate buffer.
Lotronex Tablets for oral administration contain:
- 1.124 mg alosetron HCl equivalent to 1 mg of alosetron
Each tablet also contains the inactive ingredients:
- lactose (anhydrous)
- magnesium stearate
- microcrystalline cellulose
- pregelatinized starch.
The blue film-coat contains:
- hydroxypropyl methylcellulose
- titanium dioxide
- triacetin
- indigo carmine
There may be additional Lotronex ingredients.
