Prempro or Premphase is a combination of two hormones, an estrogen and a progestin.
Prempro and Premphase are used:
Prempro or Premphase may be used as part of a program which includes weight-bearing exercise, like walking or running, and taking calcium and vitamin D supplements to reduce your chances of getting osteoporosis. Before you change your exercise habits or calcium or vitamin D intake, it is important to discuss these lifestyle changes with your healthcare provider to find out if they are safe for you. Before you make any change in your use of Prempro or Premphase, talk with your healthcare provider.
Use of postmenopausal estrogen/progestin therapy should be limited to the shortest duration consistent with treatment goals and risks for the individual woman, and should be periodically reevaluated.
Prempro therapy consists of a single tablet to be taken once daily.
Premphase therapy consists of two separate tablets; one maroon 0.625 mg Prempro tablet taken daily on days 1 through 14 and one light-blue tablet, containing 0.625 mg conjugated estrogens and 5 mg of medroxyprogesterone acetate, taken on days 15 through 28.
Patients should be monitored closely for signs of endometrial cancer, and appropriate diagnostic measures should be taken to rule out malignancy in the event of persistent or recurring abnormal vaginal bleeding.
Serious ill effects have not been reported following acute ingestion of large doses of estrogen/ progestin-containing oral contraceptives by young children. Prempro overdose may cause nausea and vomiting, and withdrawal bleeding may occur in females.
Estrogens and progestins (such as those contained in Primpro) should not be used for the prevention of cardiovascular disease. The Estrogen or progestin may cause fetal harm when administered to a pregnant woman.
2. Undiagnosed abnormal genital bleeding.
3. Known or suspected cancer of the breast.
4. Known or suspected estrogen-dependent neoplasia.
5. Active deep vein thrombosis/pulmonary embolism or a history of these conditions.
6. Active or recent arterial thromboembolic disease (eg, stroke, myocardial infarction).
7. Liver dysfunction or disease.
8. Prempro or Premphase therapy should not be used in patients hypersensitive to the ingredients contained in the tablets.
Estrogen or progestin may cause fetal harm when administered to a pregnant woman.
During menopause, some women develop nervous symptoms or depression. Estrogens do not relieve these symptoms.
Store Prempro at controlled room temperature 20°C - 25°C (68°F - 77°F).
You may have heard that taking estrogens for years after menopause will keep your skin soft and supple and keep you feeling young. There is no evidence for this.