Prempro

Prempro Information

Brand Name: Prempro

Generic Name: Generic Prempro

Other Common Names: Primpro, Premelle, Premphase

Prempro or Premphase is a combination of two hormones, an estrogen and a progestin.

Prempro and Premphase are used:

To reduce moderate to severe menopausal symptoms
To treat itching, burning, and dryness in and around the vagina due to menopause
To help reduce your chance of getting osteoporosis (thin weak bones)

Prempro or Premphase may be used as part of a program which includes weight-bearing exercise, like walking or running, and taking calcium and vitamin D supplements to reduce your chances of getting osteoporosis. Before you change your exercise habits or calcium or vitamin D intake, it is important to discuss these lifestyle changes with your healthcare provider to find out if they are safe for you. Before you make any change in your use of Prempro or Premphase, talk with your healthcare provider.

Prempro Ingredients and Composition

How To Take Prempro and Prempro Dosage and Administration

Use of postmenopausal estrogen/progestin therapy should be limited to the shortest duration consistent with treatment goals and risks for the individual woman, and should be periodically reevaluated.

Prempro therapy consists of a single tablet to be taken once daily.

For treatment of moderate-to-severe vasomotor symptoms and/or vulvar and vaginal atrophy associated with the menopause, patients should be started at the lowest effective dose Prempro 0.625 mg/2.5 mg daily. Patients should be reevaluated at 3-month to 6-month intervals to determine if treatment for symptoms is still necessary. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding. In patients where bleeding or spotting remains a problem, after appropriate evaluation, consideration should be given to increasing the medroxyprogesterone acetate (MPA) dose to PREMPRO 0.625 mg/5 mg daily. This dose should be periodically reassessed by the healthcare provider.

For prevention of postmenopausal osteoporosis Prempro 0.625 mg/2.5 mg daily. When used solely for the prevention of postmenopausal osteoporosis, alternative treatments should be carefully considered. In patients where bleeding or spotting remains a problem, after appropriate evaluation, consideration should be given to increasing the MPA dose to Prempro 0.625 mg/5 mg daily. This dose should be periodically reassessed by the healthcare provider. Patients should be monitored closely for signs of endometrial cancer, and appropriate diagnostic measures should be taken to rule out malignancy in the event of persistent or recurring abnormal vaginal bleeding.

Premphase therapy consists of two separate tablets; one maroon 0.625 mg Prempro tablet taken daily on days 1 through 14 and one light-blue tablet, containing 0.625 mg conjugated estrogens and 5 mg of medroxyprogesterone acetate, taken on days 15 through 28.

For treatment of moderate to severe vasomotor symptoms and/or vulvar and vaginal atrophy associated with the menopause. Patients should be reevaluated at 3-month to 6-month intervals to determine if treatment for symptoms is still necessary. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.

For prevention of postmenopausal osteoporosis. When Premphase is used solely for the prevention of postmenopausal osteoporosis, alternative treatments should be carefully considered.

Patients should be monitored closely for signs of endometrial cancer, and appropriate diagnostic measures should be taken to rule out malignancy in the event of persistent or recurring abnormal vaginal bleeding.

If you suspect a Prempro Overdose

Serious ill effects have not been reported following acute ingestion of large doses of estrogen/ progestin-containing oral contraceptives by young children. Prempro overdose may cause nausea and vomiting, and withdrawal bleeding may occur in females.

Prempro Side Effects

Prempro Precautions and Contraindications

Estrogens and progestins (such as those contained in Primpro) should not be used for the prevention of cardiovascular disease. The Estrogen or progestin may cause fetal harm when administered to a pregnant woman.

2. Undiagnosed abnormal genital bleeding.

3. Known or suspected cancer of the breast.

4. Known or suspected estrogen-dependent neoplasia.

5. Active deep vein thrombosis/pulmonary embolism or a history of these conditions.

6. Active or recent arterial thromboembolic disease (eg, stroke, myocardial infarction).

7. Liver dysfunction or disease.

8. Prempro or Premphase therapy should not be used in patients hypersensitive to the ingredients contained in the tablets.

Taking Prempro during Pregnancy or Breast-feeding

Estrogen or progestin may cause fetal harm when administered to a pregnant woman.

Estrogens and Depression

During menopause, some women develop nervous symptoms or depression. Estrogens do not relieve these symptoms.

Storing Prempro

Store Prempro at controlled room temperature 20°C - 25°C (68°F - 77°F).

Additional Notes

You may have heard that taking estrogens for years after menopause will keep your skin soft and supple and keep you feeling young. There is no evidence for this.