Prempro Side Effects

Prempro Information

Prempro Side Effects

Prempro or Premphase side effects include:

1. Heart disease, stroke and blood clots: The use of Prempro or Premphase may increase your chance of having a heart attack, a stroke, blood clots, a pulmonary embolus (a blood clot formed in the legs or pelvis that breaks off and travels to the lungs), retinal thrombosis (a clot in a blood vessel of the eye), or other blood clotting problems. Any of these conditions may cause death or serious long-term disability. These conditions have been seen in healthy, postmenopausal women, as well as in women with a history of heart disease.
2. Cancer of the breast: Long-term use of Prempro or Premphase may increase your chance of having breast cancer. Regular breast exams by a health professional and monthly self-exams are recommended for all women. Mammography should be scheduled depending on your age and risk factors.
3. Cancer of the uterus: Estrogens increase the risk of getting a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. The risk of cancer of the uterus increases when estrogens are used alone, the longer they are used, and when larger doses are taken. Taking progestins with estrogens lowers the risk of getting this condition. Prempro or Premphase contain estrogen and progestin.
4. Ovarian cancer: Some studies suggest that there is a greater risk of ovarian cancer in women who have used estrogen alone for a long period of time, especially 10 years or more. Other studies have not shown this risk. The risk with Prempro or Premphase treatment is unclear.
5. Vaginal bleeding: If you develop vaginal bleeding while taking Prempro or Premphase, discuss your bleeding pattern with your healthcare provider. This is because vaginal bleeding after menopause may be a warning sign of a serious condition, including cancer of the uterus.
6. Gallbladder disease: Women who use Prempro or Premphase after menopause are more likely to develop gallbladder disease needing surgery than women who do not use estrogens.
7. Blood pressure: Some women who are taking Prempro or Premphase may have increases in blood pressure.
8. Liver problems: If you had yellowing of your skin or eyes associated with pregnancy, or with taking estrogens (eg, oral contraceptives), this condition may occur again with Prempro or Premphase treatment.
9. Hypothyroidism: Women who are taking Prempro or Premphase, and who use thyroid replacement therapy may require increased doses of their thyroid medication.
10. 0. Effects on blood sugar: Taking Prempro or Premphase may affect blood sugar levels, which might make a diabetic condition worse.
11. 1. Other conditions: Fluid retention due to Prempro or Premphase treatment may make some conditions worse, such as heart disease or kidney disease. Estrogen treatment may also worsen asthma, epilepsy, migraine, porphyria and endometriosis.

Additionally Primpro or Premphase may cause the following side effects:

• Nausea, vomiting, pain, cramps, swelling, or tenderness in the abdomen.
• Breast tenderness or enlargement, pain or discharge.
• Enlargement of benign tumors ("fibroids") of the uterus.
• Change in amount of cervical secretion.
• Vaginal yeast infections.
• A spotty darkening of the skin, particularly on the face; reddening of the skin; skin rashes.
• Retention of fluid (edema).
• Headache, migraines, dizziness, or changes in vision (including intolerance to contact lenses).
• Mental depression.
• Involuntary muscle spasms.
• Hair loss or abnormal hairiness.
• Increase or decrease in weight.
• Changes in sex drive.

Prempro Information