Synephrine Clinical Trials and Studies
Synephrine Information
Synephrine Clinical Trials and Studies
The effects of synephrine alone or in combination with other ingredients such as kola nut and guarana (both are caffeine sources) or with salicylates such as white willow (a natural form of aspirin) generally fall into the category of acting as a mild stimulant. The extract of citrus aurantium, in addition to synephrine, also contains tyramine and octopamine. Octopamine may be related in some way to appetite control, as it is thought to influence insect behavior by stopping bugs from eating the citrus fruit (so if you're an insect, this may be the perfect weight loss supplement for you).
A recent synephrine / Citrus aurantium study conducted in dogs suggests that synephrine and octopamine can increase metabolic rate in a specific type of fat tissue known as brown adipose tissue (BAT). This effect would be expected to increase fat loss in humans – except for one small detail – adult humans don't have brown adipose tissue to speak of.
Up until very recently, synephrine-containing supplements existed with only some interesting theories on how they might work to increase metabolic rate and promote significant weight loss. At this writing, there are now at least two clinical studies showing that synephrine-containing supplements help promote weight loss, and at least three clinical studies showing an enhanced thermogenesis (calorie expenditure) from these supplements. There is a great deal of research currently underway into the weight loss benefits of synephrine and supplements with related thermogenic effects, leading researchers in the Department of Physiology at Georgetown University to conclude that "Citrus aurantium may be the best thermogenic substitute for ephedra."
