Trim Spa Clinical Trials and Studies
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Trim Spa Clinical Trials and Studies
Ephedrine and Caffeine
Renowned weight-loss expert Arne Astrup, MD, and his associates performed a study with ephedrine at the University of Copenhagen and two Danish hospitals. Five young females were given 20 mg of ephedrine three times per day one hour before meals and were told to continue eating normally (note the this is the method of taking Trim Spa). Even though there was no dieting involved, the women lost an average of 2.5 kg of body weight after four weeks and 5.5 kg after 12 weeks. They also held onto their lean muscle, while their body-fat percentage dropped by 3.5% after four weeks and 5.2% after 12 weeks. Two months after the experiment stopped, they had only gained back 0.5 kg. The only side effect was a mild rise in blood pressure at the start of the experiment.
Two studies by the same Danish researchers indicate the benefits of combining ephedrine with caffeine. In both studies, the participants took a supplement with 20 mg of ephedrine and 200 mg of caffeine three times per day. They also followed a low-calorie diet. In the first study, the test subjects lost 16.2% of their body weight in 24 weeks, significantly more than the 13.4% loss by the placebo group. The second study confirmed that most of this loss was body fat. In that eight-week study, the E/C group lost 10.1 kg, compared to only 8.4 kg with the placebo. But the E/C group lost twice as much fat (9.0 kg vs. 4.5 kg) and much less fat-free mass (1.1 kg vs. 3.9 kg). Only mild side effects were reported.
The E/C combination has been extensively studied, but space limitations do not allow a detailed listing of the many studies that have showed benefits. All of this research, however, supports the effectiveness of the ECA stack in thermogenics such as Trim Spa and demonstrates the moderate level of side effects when you take appropriate dosages.
L-tyrosine
Research suggests that supplementing with tyrosine may minimize the degradation of the neurotransmitters involved in the metabolic process while enhancing the thermogenic effects of the ephedrine/caffeine stack. With more raw material available, the neurotransmitters controlling metabolism are produced at a higher level with beneficial results. The increases in alertness and energy level will also make it easier to stick to your diet program.
Ginger root
Ginger has a long history of use as a treatment for motion sickness. In one double-blind, placebo-controlled study by Danish researchers, naval cadets unaccustomed to sailing in rough seas were given 1 gm of ginger root or placebo every hour for four hours. The ginger root reduced the tendency toward vomiting and cold sweating. Thermogenic formulations such as Trim Spa only produce gastrointestinal distress in some sensitive individuals, so ginger should definitely be able to relieve these much milder symptoms. There are no studies showing that ginger by itself has fat-burning properties.
Citrus bioflavonoids
Numerous studies have indicated that the citrus bioflavonoid naringin prolongs the chemical activity of caffeine. Research published in the British Journal of Clinical Pharmacology found that the half-life of caffeine was extended by 31% when naringin was present in sufficient amounts. Studies of various citrus fruits have shown that grapefruit has by far the highest content of naringin. It is, in fact, what gives grapefruit its characteristic bitter taste. The activity of other citrus bioflavonoids has not been studied.
Cayenne and other peppers
The capsaicin in cayenne has been shown to be effective in animal and human experiments. In a recent 14-day study, rats were given capsaicin or placebo and put on an exercise program. Compared to the control rats, the capsaicin group had a greater reduction in their fat stores. These benefits appear to take place with both high-carb and high-fat diets. A study of Japanese women on these two types of diets found that adding cayenne to their food led to increased energy expenditure and fat oxidation. Both of these effects would result in a loss of body fat over time. The extent of the benefits from black pepper and long pepper has not been clarified by scientific research.
Cinnamon
Cinnamon has been shown in scientific studies to have numerous benefits related to its antiviral and antibacterial activity. However, while it is traditionally recommended to treat fatigue, no study has examined its ability to actually increase thermogenesis induced by Trim Spa or metabolic rate.
Chromium dinicotinate glycinate
The studies on chromium are all over the board. While it can be very helpful for diabetics, the demonstrated benefits (or lack thereof) for nondiabetics depend on the nutritional status of the participants and the amount and length of the supplementation program. One study that did show a benefit from the use of chromium picolinate was presented at the national meeting of the Federation of American Societies for Experimental Biology in 2000. This study found a 40% increase in glucose uptake into muscle tissue compared to the placebo group.
Since insulin can also transport glucose to the fat cells for storage, these results suggest that chromium helps to shunt the glucose towards the active working tissues where it can be burned for energy. The end result could well be a loss in body fat, although this benefit was not measured. The bottom line is that chromium is an essential nutrient that is often deficient in most people's diets. Eliminating this deficiency should at a minimum increase your adherence to your diet by improving your energy levels and reducing mood swings.
Methionine
Methionine is an amino acid that must be obtained from the diet, as the body cannot manufacture it. It assists in fat breakdown (lipolysis), although it has many other roles in the body. Methionine is included in fat-burner formulations because of its ability to support greater levels of fatty-acid oxidation. However, it has not been studied as a fat burner on its own, so it is not known how much methionine is needed to promote significant levels of fat loss.
Siberian ginseng
Siberian ginseng is widely regarded as an effective herb for promoting the health of the adrenal glands. A study published in Naval Research Review found that Siberian ginseng has a tonic effect on the adrenal glands, reducing the production of the catabolic hormone cortisol. Additional studies have shown that this herb has an anti-inflammatory effect and that it strengthens the immune system through its adaptogenic actions.
Other ingredients
Most of the other ingredients in Trim Spa's formulation have (at best) anecdotal evidence of their effectiveness. Virtually none of them have been subject to the kind of scientific scrutiny that is needed to clearly support their use as fat burners. Although vanadium has been shown to improve insulin sensitivity in diabetics, its effectiveness in nondiabetics is unproven. Also, while glucosamine is a valuable nutrient for your joints, its ability to act as a "thermogenic maximizer" is questionable. Moreover, since these ingredients are provided in such low dosages, they cannot significantly contribute to the product's effectiveness.
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