Uprima

Uprima Information

Common Names: Uprima, Uprime

Uprima is a prescription medication used for the treatment of erectile dysfunction or ED. Erectile dysfunction is a condition in which a man cannot achieve an erection sufficient enough for intercourse. Uprima helps men achieve erections by stimulating the region of the brain called the hypothalamus. As a result of a dose of Uprima, the body increases the production of dopamine, an important chemical in the body that helps trigger erection.

Uprima Ingredients and Composition

How Does Uprima Work?

Uprima (apomorphine) is a dopaminergic agonist with affinity for both D1 and D2 receptors in sites within the brain known to be involved in the mediation of erection. Uprima studies in vivo have shown the erectile function effects of apomorphine are mediated at dopamine receptors in various nuclei in the hypothalamus and midbrain. In particular, the paraventricular nucleus of the hypothalamus has been identified as the site of action. This site may mediate autonomic aspects of sexual arousal. Oxytocinergic and nitric oxide signalling may be involved in the cascade of neural events that result from the central action of apomorphine.

Apomorphine acts as a central initiator of erection and enhances pro-erectile stimuli. The erectogenic effects of Uprima arise from improved central neural signalling specific to penile vascular response.

In simple terms:

Uprima, unlike other oral treatments for erectile dysfunction, stimulates dopamine receptors in the brain. These receptors in turn transmit excitatory signals down the spinal cord to the sacral parasympathetic nucleus, stimulating activity of the sacral nerves supplying the penis. As the penile smooth muscle relaxes, the pelvic arteries dilate. The dilated arteries then fill with blood and the penis becomes erect.

How To Take Uprima and Uprima Dosage and Administration

It is recommended that you take the Uprima sublingual tablet 20 minutes prior to sexual activity. It is best to drink a small glass of water before taking the Uprima tablet to help the dissolving process.

After drinking the water, place the Uprima tablet under the tongue. Do not chew, just let the tablet dissolve. In the majority of patients, the Uprima tablet will be dissolved within 10 minutes. An erection should occur when sexual activity starts.

It might take about 10 minutes for the Uprima tablet to dissolve. Sexual stimulation is required for the drug to take effect, and for an erection to be achieved. For most patients, Uprima should be taken once a day as required. Take one Uprima tablet in an eight-hour period. Do not exceed 2 mg within an 8 hour period, as serious complications can occur.

If you suspect a Uprima Overdose

Uprima may incude vomiting if taken in high doses. If Uprima tablets are swallowed, the absorption of apomorphine will be reduced by first-pass hepatic metabolism. There is no specific antidote available for Uprima. Treatment should be supportive and symptomatic. It is advised that vital signs, such as blood pressure and heart rate, be monitored. Measures to avoid possible orthostatic hypotension should be taken. The use of domperidone maleate, a peripherally acting dopamine antagonist used to counter emetic effects, may be considered in case of an Uprima overdose.

Uprima Side Effects

Uprima Precautions and Contraindications

Uprima is a prescription medication intended for use in generally healthy male patients. It is not approved for women or children.

Do not administer Uprima if:

You have ever had an allergic reaction to apomorphine or any other ingredients found in Uprima.
You suffer from severe unstable angina, recent myocardial infarction, severe heart failure, hypertension, or any other heart problems.
Your partner is pregnant or breast-feeding.

If you fall under any one of the following conditions, use extra precautions and consult your doctor before taking Uprima:

You have a deformity or disease of the penis.
You experience severe dizziness or feel faint after taking Uprima.
You are taking medications with nitrates.
You have liver or kidney problems.
You have suffer from hypertension (high blood pressure).
You are taking other treatments for erectile dysfunction.

Uprima Clinical Trials and Studies

Storing Uprima

Keep Uprima out of reach and sight of children. Store Uprima in the original package. Do not use Uprima after the expiration date shown, or if the pack has been damaged or tampered with.