Valdure
Valdure Information
Brand Name: Bextra
Generic Name: Valdecoxib
Other Common Names: Valdure
Bextra tablets are indicated for:
- For relief of the signs and symptoms of osteoarthritis and adult rheumatoid arthritis.
- For the treatment of primary dysmenorrhea.
Valdure Ingredients and Composition
How Does Valdure Work?
Mechanism of Action
Valdecoxib, the active ingredient in Bextra, is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of cyclooxygenase-2 (COX-2). At therapeutic plasma concentrations in humans Bextra (valdecoxib) does not inhibit cyclooxygenase-1 (COX-1).
How To Take Valdure and Valdure Dosage and Administration
Osteoarthritis and Adult Rheumatoid Arthritis
The recommended dose of Bextra Tablets for the relief of the signs and symptoms of arthritis is 10 mg once daily.
Primary Dysmenorrhea
The recommended dose of Bextra Tablets for treatment of primary dysmenorrhea is 20 mg twice daily, as needed.
If you suspect a Valdure Overdose
Symptoms following acute Bextra (and other NSAIDs) overdoses are usually limited to:
- lethargy
- drowsiness
- nausea
- vomiting
- epigastric pain
These are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare.
Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs such as Bextra, and may occur following an overdose.
Patients should be managed by symptomatic and supportive care following an NSAID overdose. There are no specific antidotes. Hemodialysis removed only about 2% of administered valdecoxib (active Bextra ingredient) from the systemic circulation of 8 patients with end-stage renal disease and, based on its degree of plasma protein binding (>98%), dialysis is unlikely to be useful in overdose. Forced diuresis, alkaliniza-tion of urine, or hemoperfusion also may not be useful due to high protein binding.
Valdure Side Effects
Valdure Precautions and Contraindications
Patients taking Bextra should report to their physicians, signs or symptoms of gastrointestinal ulceration or bleeding, skin rash, weight gain, or edema.
Patients should be informed of the warning signs and symptoms of hepatotoxicity (e.g.,nausea, fatigue, lethargy, pruritus, jaundice, right upper quadrant tenderness, and flu-like symptoms).If these occur, patients should be instructed to stop Bextra therapy and seek immediate medical attention.
Patients should also be instructed to seek immediate emergency help in the case of an anaphylactoid reaction after taking Bextra.
Contraindications to Valdure
Bextra Tablets are contraindicated in patients with known hypersensitivity to valdecoxib. Bextra should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs are possible in such patients.
Bextra should not be given to patients who have demonstrated allergic-type reactions to sulfonamides.
Valdure Warnings
Valdure Clinical Trials and Studies
Storing Valdure
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)
