Yohimbine

Yohimbine Information

Yohimbine (yo-HIM-been) is used to increase peripheral blood flow. It is also used to dilate the pupil of the eye.

Yohimbine is an alpha-adrenoceptor blocker that has been used in the treatment of erectile dysfunction.

Yohimbine Ingredients and Composition

How Does Yohimbine Work?

In order to understand the Yohimbine mechanism od action, one must forst understand what is norepinephrine, and how it works. Norepinephrine is a hormone secreted by the medulla of the adrenal glands, that acts as a neurotransmitter. The sympathetic nervous system functions in response to short-term stress; hence norepinephrine increases the heart rate as well as blood pressure. Other actions of norepinephrine include increased glycogenolysis (the conversion of glycogen to glucose) in the liver, increased lipolysis (the conversion of fats to fatty acids) in adipose (fat) tissue, and relaxation of bronchial smooth muscle to open up the air passages to the lungs. All of these actions represent a mobilization of the body's resources in order to meet the stressful challenge; such a response is often termed the 'flight or fight' syndrome, and can be used to facilitate weight loss

Yohimbine is a selective alpha 2 antagonist and can saturate the alpha 2 receptors, cancelling the norepinephrine production-stop that they will initiate upon binding with n repinephrine, thus short circuit this feedback loop, maximizing NE levels, thus maximizing fat loss, particularly in these problem areas -- and even more so if we can achieve high levels of yohimbine and NE in the adipose tissue. Unfortunately, to do so with orals, or any other method that results in high blood levels means that we will also have high levels in the heart and CNS -- thus, we will also have unpleasant and dangerous side effects. Considering the subject of this article, I obviously believe the solution lies in transdermal administration, but more on that in a bit.

How To Take Yohimbine and Yohimbine Dosage and Administration

Take Yohimbine only as directed by your doctor to help your condition as much as possible. Do not take more or less of it, and do not take it more or less often than your doctor ordered.

If You Miss a Dose of Yohimbine

If you miss a Yohimbine dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Yohimbine Side Effects

Yohimbine Precautions and Contraindications

For yohimbine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to yohimbine or any of the rauwolfia alkaloids, such as deserpidine (e.g, Harmonyl), rauwolfia serpentina (e.g., Raudixin), or reserpine (e.g., Serpalan). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Older adults

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of yohimbine in the elderly with use in other age groups, this medicine has been used in some elderly patients and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine before starting Yohimbine.

Other medical problems

The presence of other medical problems may affect the use of yohimbine. Make sure you tell your doctor if you have any other medical problems, especially:

Yohimbine Clinical Trials and Studies

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